Departamento de Psicología, University of Jaén, Jaén, Spain.
Behav Med. 2012 Jan;38(1):12-8. doi: 10.1080/08964289.2011.647118.
This study analyzed the relationship between some psychosocial variables (depression, anxiety, stress, coping strategies, social support, optimism, rationality, and need for harmony) and clinical parameters indicative of immunological response after bone marrow transplantation (BMT; day of engraftment, number of infections and hemoglobin level) while controlling for demographic variables (age, educative level, civil state, and time from cancer diagnosis). Thirty-one post BMT hematological cancer patients were evaluated. Results show that higher educative levels are associated to lower number of infections, while age is associated with a delay in the time of engraftment; coping strategies, specially redefinition of the situation, relaxation, stoicism and passivity, are positively associated with the three clinical indices; depression is positively associated to number of infections during the hospitalization period; and rationality is associated with lower hemoglobin levels. These results suggest that psychosocial variables, especially coping strategies, play an important role in determining the immunological response after BMT.
本研究分析了一些心理社会变量（抑郁、焦虑、压力、应对策略、社会支持、乐观、理性和和谐需求）与骨髓移植（BMT）后免疫反应的临床参数之间的关系（植入日、感染次数和血红蛋白水平），同时控制了人口统计学变量（年龄、教育水平、公民身份和癌症诊断后的时间）。对 31 名 BMT 后血液系统癌症患者进行了评估。结果表明，较高的教育水平与感染次数较少有关，而年龄与植入时间延迟有关；应对策略，特别是重新定义情况、放松、坚忍和被动，与三个临床指标呈正相关；抑郁与住院期间感染次数呈正相关；理性与较低的血红蛋白水平相关。这些结果表明，心理社会变量，特别是应对策略，在确定骨髓移植后的免疫反应中起着重要作用。
