Neal D E, Dilworth J P, Kaack M B, Didier P, Roberts J A
Department of Urology, Delta Regional Primate Research Center, Covington, Louisiana 70433.
Prostate. 1990;17(3):233-9. doi: 10.1002/pros.2990170307.
Bacterial prostatitis is a common cause of urinary tract infection in males, but little is known of its pathophysiology. To study this, we developed a nonhuman primate model using a wild-type clinical isolate of Escherichia coli. Primates have a prostatic anatomy that is similar to humans, which makes them ideal as an animal model of this disease. The monkeys had a urethral inoculation of this organism and were then followed with urine, blood, and semen cultures, white blood counts, and renal scans. They were sacrificed at from 10 days to 4 weeks, and their genitourinary tracts histologically examined. The prostatitis paralleled that reported in humans, and we conclude that the infection occurs by the ascending route. The organisms causing the infection in man do so in our primate model, and the histologic change is also the same. Thus, the primate model holds promise for studies to help us understand this disease.
细菌性前列腺炎是男性尿路感染的常见病因，但其病理生理学却鲜为人知。为了对此进行研究，我们利用一株野生型临床分离的大肠杆菌建立了一个非人灵长类动物模型。灵长类动物的前列腺解剖结构与人类相似，这使其成为这种疾病理想的动物模型。给猴子经尿道接种这种微生物，然后对其进行尿液、血液和精液培养、白细胞计数以及肾脏扫描跟踪观察。在10天至4周后将它们处死，并对其泌尿生殖道进行组织学检查。前列腺炎情况与人类报告的相似，我们得出结论，感染是通过上行途径发生的。在人类中引起感染的病原体在我们的灵长类动物模型中也是如此，而且组织学变化也是相同的。因此，灵长类动物模型有望用于研究，以帮助我们了解这种疾病。
