Department of Experimental Medicine and Oncology Section of General Pathology, University of Turin C. Raffaello, 30, 10125, Turin, Italy.
Cytotechnology. 1993 Jan;11(Suppl 1):S62-4. doi: 10.1007/BF00746057.
The antiproliferative action of 4-hydroxynonenal (HNE) could be related to an interaction with cytoskeletal structures. In this paper the effects exerted by HNE on microtubules and on microfilaments are examined by immunofluorescence. HNE alters cell morphology causing both the depolymerization of the microtubular structures and the dissolution of the stress-fibres. Taxol protects microtubules, preventing the depolymerizing effect of the aldehyde. The action of HNE could be attributed to its affinity for sulphydryl groups, which are essential in maintaining tubulin and actin both in the polymerized form.
4-羟壬烯醛（HNE）的抗增殖作用可能与其与细胞骨架结构的相互作用有关。本文通过免疫荧光法研究了 HNE 对微管和微丝的作用。HNE 改变细胞形态，导致微管结构解聚和应力纤维溶解。紫杉醇保护微管，防止醛的解聚作用。HNE 的作用可以归因于其对巯基的亲和力，而巯基对于维持微管蛋白和肌动蛋白的聚合形式是必不可少的。
