Cytotechnology. 1997 Nov;25(1-3):239-41. doi: 10.1023/A:1007939127679.
Two hundreds species of marine algae were investigated for in vitro promoting activity of human interferon β (IFN-β) production by poly(I:C)-induced human osteosarcoma cell line, MG-63. A brown alga, Sargassum hemipyllum promoted most its activity, showing more than 11-fold. When we attempted to partially purify the active substances by particular two-step chromatography, two peaks of active fractions were obtained. These fractioned materials exhibited the heat-stable and non-cytotoxic characters with the molecular weight less than 3000.
我们研究了两百种海洋藻类，以评估它们对聚肌苷酸-聚胞苷酸（poly(I:C)）诱导的人骨肉瘤细胞系 MG-63 产生人干扰素 β（IFN-β）的体外促进活性。一种褐藻，半叶马尾藻（Sargassum hemipyllum）表现出最强的活性，其活性超过 11 倍。当我们试图通过特定的两步色谱法对活性物质进行部分纯化时，得到了两个具有活性的馏分峰。这些分馏物质具有热稳定性和非细胞毒性特征，分子量小于 3000。
