Molecular Physiology Laboratory, Departament de Bioquímica i Biologia Molecular, Institut de Biomedicina, Universitat de Barcelona, Spain.
Cancer Invest. 2012 Mar;30(3):203-8. doi: 10.3109/07357907.2012.654872.
Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.
由于 Kv1.3 和 Kv1.5 K(+) 通道在肿瘤发生过程中发生重构，并参与骨骼肌增殖，我们分析了它们在人类骨骼肌肉瘤中的表达。研究了侵袭性肺泡横纹肌肉瘤 (ARMS) 和胚胎横纹肌肉瘤 (ERMS)。Kv1.5 在成人肌肉中的表达中等，在 ERMS 中较低，而在 ARMS 和胚胎样本中则很明显。Kv1.3 在 RMS 和健康样本之间的表达没有明显差异。我们发现 Kv1.3 和 Kv1.5 的表达与肿瘤恶性程度相关。
