来自西沙群岛海绵 Agelas mauritiana 的抗菌代谢产物。
Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.
机构信息
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
出版信息
J Nat Prod. 2012 Apr 27;75(4):774-8. doi: 10.1021/np2009016. Epub 2012 Feb 23.
Abstract
Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.
摘要
从海洋海绵 Agelas mauritiana 中分离得到了四个新的生物碱：(-)-8'-氧代-阿格洛辛 D（2）、阿格洛肟 B（3）、（+）-2-氧代-阿格洛辛 C（4）和 4-溴-N-（丁氧基甲基）-1H-吡咯-2-甲酰胺（5），以及已知化合物（-）-阿格洛肟 D（1）。基于光谱分析确定了它们的化学结构。化合物 1 和 3 均表现出对新型隐球菌的抗真菌活性和对利什曼原虫的抗利什曼原虫活性。化合物 3 还表现出对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌的体外抗菌活性。
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