Cambridge G, MacArthur C G, Waterson A P, Goodwin J F, Oakley C M
Br Heart J. 1979 Jun;41(6):692-6. doi: 10.1136/hrt.41.6.692.
Fifty patients with congestive cardiomyopathy have been studied for evidence of previous Coxsackie B virus infection and compared with age- and sex-matched controls who had been admitted to hospital for investigation of other cardiac diseases. High neutralisation titres (greater than or equal to 1024) to Coxsackie B viruses were more common among the controls. On subdividing the patients according to their length of symptomatic history before study, high titres were more common only in those with a short history (less than or equal to 1 year). High titres were more common when there had been a febrile illness at the onset of symptoms. Endomyocardial biopsies of 18 patients disclosed no evidence of myocarditis, or, in 12 cases, of viral involvement. Although the evidence remains circumstantial, these results support the theory that Coxsackie B viruses may cause congestive cardiomyopathy and encourage further research into the mechanisms of myocardial cell damage by these visuses.
对50例充血性心肌病患者进行了研究，以寻找既往柯萨奇B病毒感染的证据，并与因其他心脏疾病入院检查的年龄和性别匹配的对照组进行比较。对照组中对柯萨奇B病毒的高中和滴度（大于或等于1024）更为常见。根据研究前症状史的长短对患者进行细分，高滴度仅在病史较短（小于或等于1年）的患者中更为常见。症状发作时有发热性疾病时，高滴度更为常见。18例患者的心内膜心肌活检未发现心肌炎证据，12例未发现病毒感染证据。尽管证据仍然是间接的，但这些结果支持柯萨奇B病毒可能导致充血性心肌病的理论，并鼓励对这些病毒导致心肌细胞损伤的机制进行进一步研究。
