人类感染 H5N1 流感的血清学证据：荟萃分析。
Seroevidence for H5N1 influenza infections in humans: meta-analysis.
机构信息
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
出版信息
Science. 2012 Mar 23;335(6075):1463. doi: 10.1126/science.1218888. Epub 2012 Feb 23.
Abstract
The prevalence of avian H5N1 influenza A infections in humans has not been definitively determined. Cases of H5N1 infection in humans confirmed by the World Health Organization (WHO) are fewer than 600 in number, with an overall case fatality rate of >50%. We hypothesize that the stringent criteria for confirmation of a human case of H5N1 by WHO do not account for a majority of infections but rather the select few hospitalized cases that are more likely to be severe and result in poor clinical outcome. Meta-analysis shows that 1 to 2% of more than 12,500 study participants from 20 studies had seroevidence for prior H5N1 infection.
摘要
人类中禽流感 H5N1 感染的流行情况尚未得到明确确定。世界卫生组织（WHO）确认的人类 H5N1 感染病例数不到 600 例，总病死率>50%。我们假设，WHO 对人类 H5N1 病例的确认标准过于严格，未能涵盖大多数感染病例，而只是少数住院的严重病例，导致临床预后不良。荟萃分析显示，在来自 20 项研究的超过 12500 名研究参与者中，有 1%至 2%的人具有 H5N1 既往感染的血清学证据。
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