Katz J M, Lim W, Bridges C B, Rowe T, Hu-Primmer J, Lu X, Abernathy R A, Clarke M, Conn L, Kwong H, Lee M, Au G, Ho Y Y, Mak K H, Cox N J, Fukuda K
Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
J Infect Dis. 1999 Dec;180(6):1763-70. doi: 10.1086/315137.
The first documented outbreak of human respiratory disease caused by avian influenza A (H5N1) viruses occurred in Hong Kong in 1997. The kinetics of the antibody response to the avian virus in H5N1-infected persons was similar to that of a primary response to human influenza A viruses; serum neutralizing antibody was detected, in general, >/=14 days after symptom onset. Cohort studies were conducted to assess the risk of human-to-human transmission of the virus. By use of a combination of serologic assays, 6 of 51 household contacts, 1 of 26 tour group members, and none of 47 coworkers exposed to H5N1-infected persons were positive for H5 antibody. One H5 antibody-positive household contact, with no history of poultry exposure, provided evidence that human-to-human transmission of the avian virus may have occurred through close physical contact with H5N1-infected patients. In contrast, social exposure to case patients was not associated with H5N1 infection.
首次有记录的由甲型禽流感（H5N1）病毒引起的人类呼吸道疾病暴发于1997年在香港发生。H5N1感染患者对禽流感病毒的抗体反应动力学与对甲型人流感病毒的初次反应相似；一般在症状出现后≥14天检测到血清中和抗体。开展了队列研究以评估该病毒人传人的风险。通过使用多种血清学检测方法，51名家庭接触者中有6人、26名旅行团成员中有1人以及47名接触H5N1感染患者的同事中无人H5抗体呈阳性。一名无家禽接触史的H5抗体阳性家庭接触者提供了证据，表明禽流感病毒可能通过与H5N1感染患者的密切身体接触发生了人传人。相比之下，与病例患者的社交接触与H5N1感染无关。
