Kamala Arunagiri, Middha Sushil Kumar, Karigar Chandrakant S
1Department of Studies and Research in Biochemistry, Tumkur University, Tumkur, Karnataka India.
2DBT-BIF Facility, Department of Biotechnology, Maharani Lakshmi Ammanni College for Women, Science Post, Malleswaram, Bangalore, Karnataka India.
3 Biotech. 2018 Jul;8(7):309. doi: 10.1007/s13205-018-1328-6. Epub 2018 Jul 9.
The nutgrass, L. (Family: Cyperaceae), is a colonial, perennial herb considered to have originated in India 2000 years ago and widely used in Ayurveda to treat several ailments. In addition to its prehistoric uses, it is used in several systems of medicine for treating variety of diseases. The synergistic actions of the ' compounds have added advantage over that of a single constituent. In the past decade, numerous studies proved analgesic, anti-allergic, anti-arthritic, anti-candida, anti-cariogenic, anti-convulsant, anti-diarrheal, anti-emetic, anti-helminthic, anti-histamine, anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-malarial, anti-obesity, antioxidant, anti-platelet, anti-pyretic, anti-ulcer, anti-viral, cardioprotective, cytoprotective, cytotoxic, gastroprotective, hepatoprotective, neuroprotective, ovicidal, and larvicidal, wound healing and inhibition of brain Na K ATPase activities of and its chemical constituents. However, the exact the mechanism of action is not very clear and requires further evaluation. These properties strongly suggest an extensive use of for clinical applications. In this review, we attempted to provide information about the pharmacological effects of and its proposed mechanisms of actions.
香附子,莎草科,是一种丛生多年生草本植物,被认为起源于2000年前的印度,在阿育吠陀医学中被广泛用于治疗多种疾病。除了其史前用途外,它还被用于多种医学体系来治疗各种疾病。这些化合物的协同作用比单一成分具有更大优势。在过去十年中,大量研究证明了香附子及其化学成分具有镇痛、抗过敏、抗关节炎、抗念珠菌、抗龋齿、抗惊厥、止泻、止吐、抗蠕虫、抗组胺、降血糖、降血压、抗炎、抗疟疾、抗肥胖、抗氧化、抗血小板、退热、抗溃疡、抗病毒、心脏保护、细胞保护、细胞毒性、胃保护、肝脏保护、神经保护、杀卵和杀幼虫、伤口愈合以及抑制脑钠钾ATP酶活性等作用。然而,确切的作用机制尚不完全清楚,需要进一步评估。这些特性强烈表明香附子在临床应用中有广泛用途。在本综述中,我们试图提供有关香附子药理作用及其作用机制的信息。