Abou Diane, Benabdallah Nadia, Jiang Wen, Peng Lu, Zhang Hanwen, Villmer Alexandria, Longtine Mark S, Thorek Daniel L J
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States.
Program in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, MO, United States.
Front Oncol. 2020 Jun 5;10:884. doi: 10.3389/fonc.2020.00884. eCollection 2020.
Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. This review article summarized clinically translated approaches to detect, characterize, and treat disease in this rapidly expanding field.
转移性前列腺癌无法治愈，因此需要新的方法来更早地检测该疾病并指导确定性治疗。将诊断性和细胞毒性放射性核素有效载荷定位到癌细胞及其周围微环境的分子特异性工具被认为是对抗这种疾病的新方法的关键组成部分。对前列腺癌患者实施诊疗一体化方法以进行疾病特征描述和个性化治疗管理已开始成为现实。这篇综述文章总结了在这个 rapidly expanding field（快速发展的领域）中用于检测、表征和治疗疾病的临床转化方法。 （注：原文中“rapidly expanding field”直译为“快速扩张的领域”，结合语境意译为“快速发展的领域”更合适）
