Tjon Pian Gi Robin E A, San Giorgi Michel R M, Slagter-Menkema Lorian, van Hemel Bettien M, van der Laan Bernard F A M, van den Heuvel Edwin R, Dikkers Frederik G, Schuuring Ed M D
Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Graduate School of Medical Sciences (Groningen University Institute for Drug Exploration), University of Groningen, The Netherlands.
Head Neck. 2015 Nov;37(11):1625-32. doi: 10.1002/hed.23808. Epub 2014 Sep 12.
Recurrent respiratory papillomatosis (RRP) is mainly associated with human papillomavirus (HPV)6 or HPV11. The purpose of this study was to compare clinical outcome, aggressiveness, and treatment response between HPV6- and HPV11-associated RRP.
A retrospective cohort of 55 patients with RRP (1974-2012) was used. Surgical interventions (n = 814) were analyzed, and complications scored. HPV6/11-specific polymerase chain reaction (PCR) was performed on RRP biopsies.
Seventy-six percent of patients (42 of 55) were infected with HPV6 and 24% (13 of 55) with HPV11. The HPV11 group had anatomically more widespread disease. The expected number of surgical interventions was higher in the younger age (<22.4 years) HPV11 group, and the older age (<22.4 years) HPV6 group. Regardless of HPV type, earlier age of onset of RRP resulted in a higher number of surgical interventions.
Anatomically, HPV11-associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP.
复发性呼吸道乳头状瘤病（RRP）主要与人乳头瘤病毒（HPV）6型或HPV11型相关。本研究的目的是比较HPV6型和HPV11型相关RRP的临床结局、侵袭性和治疗反应。
采用回顾性队列研究，纳入55例RRP患者（1974 - 2012年）。分析手术干预情况（n = 814），并对并发症进行评分。对RRP活检组织进行HPV6/11特异性聚合酶链反应（PCR）检测。
76%的患者（55例中的42例）感染HPV6型，24%（55例中的13例）感染HPV11型。HPV11型组的疾病在解剖学上分布更广泛。在年龄较小（<22.4岁）的HPV11型组和年龄较大（<22.4岁）的HPV6型组中，预期的手术干预次数更高。无论HPV类型如何，RRP发病年龄越早，手术干预次数越多。
在解剖学上，HPV11型相关RRP的侵袭性更强。HPV11型的年轻患者和HPV6型的老年患者RRP的临床病程更差。
