Ouda Amr Mohamed, Elsabagh Ahmed Adel, Elmakaty Ibrahim Mohamed, Gupta Ishita, Vranic Semir, Al-Thawadi Hamda, Al Moustafa Ala-Eddin
College of Medicine, QU Health, Qatar University, Doha 2713, Qatar.
Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha 2713, Qatar.
Life (Basel). 2021 Nov 22;11(11):1279. doi: 10.3390/life11111279.
Recurrent Respiratory Papillomatosis (RRP) is a rare but severe manifestation of human papillomavirus (HPV). As our knowledge about HPV infections has expanded, it has become possible to understand the course of RRP disease and unravel plausible efficient methods to manage the disease. However, the surge in reports on HPV has not been accompanied by a similar increase in research about RRP specifically. In this paper, we review the clinical manifestation and typical presentation of the illness. In addition, the pathogenesis and progression of the disease are described. On the other hand, we discuss the types of treatments currently available and future treatment strategies. The role of vaccination in both the prevention and treatment of RRP will also be reviewed. We believe this review is essential to update the general knowledge on RRP with the latest information available to date to enhance our understanding of RRP and its management.
复发性呼吸道乳头状瘤病（RRP）是一种由人乳头瘤病毒（HPV）引起的罕见但严重的病症。随着我们对HPV感染的了解不断深入，已能够理解RRP疾病的病程，并找到合理有效的治疗方法。然而，HPV报告数量的激增并未伴随针对RRP的研究有类似增长。在本文中，我们回顾了该疾病的临床表现和典型症状。此外，还描述了疾病的发病机制和进展。另一方面，我们讨论了目前可用的治疗类型和未来的治疗策略。还将回顾疫苗接种在RRP预防和治疗中的作用。我们认为，本次综述对于用最新信息更新RRP的一般知识至关重要，有助于加深我们对RRP及其管理的理解。
