Department of Microbiology, School of Medicine, Chonnam National University, Gwangju, 501-746, Republic of Korea.
J Microbiol. 2012 Feb;50(1):137-42. doi: 10.1007/s12275-012-1286-3. Epub 2012 Feb 27.
While it is generally accepted that Propionibacterium acnes is involved in the development of acne, other bacteria including Staphylococcus epidermidis have also been isolated from the acne lesion. The interaction between Lactobacillus reuteri, a probiotic bacterium, and acnegenic bacteria is unclear. This study examined the effects of L. reuteri on the proliferation of P. acnes and S. epidermidis. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of P. acnes and S. epidermidis. The proliferation of P. acnes was decreased by 2-log scales after incubation with L. reuteri for 24 h. In addition, the proliferation of S. epidermidis was decreased by 3-log scales after incubation with L. reuteri for 24 h, whereas the growth of L. reuteri was unaffected by P. acnes or S. epidermidis. Among the L. reuteri strains examined, L. reuteri KCTC 3679 had the strongest inhibitory effect on the growth of P. acnes and S. epidermidis, followed by L. reuteri KCTC 3594 and L. reuteri KCTC 3678. Interestingly, reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. The most pronounced the antibacterial activities of L. reuteri were attributed to the production of organic acids. Overall, these results suggest that L. reuteri may be a useful probiotic agent to control the growth of bacteria involved in acne inflammation and prevent acne.
虽然普遍认为痤疮丙酸杆菌与痤疮的发生有关，但其他细菌，包括表皮葡萄球菌，也已从痤疮病变中分离出来。益生菌细菌罗伊氏乳杆菌与痤疮相关细菌之间的相互作用尚不清楚。本研究检查了罗伊氏乳杆菌对痤疮丙酸杆菌和表皮葡萄球菌增殖的影响。使用了人源罗伊氏乳杆菌菌株（KCTC 3594 和 KCTC 3678）和大鼠源罗伊氏乳杆菌 KCTC 3679。所有菌株对痤疮丙酸杆菌和表皮葡萄球菌的生长均表现出显著的抑制作用。在孵育 24 小时后，痤疮丙酸杆菌的增殖减少了 2 个对数级。此外，在孵育 24 小时后，表皮葡萄球菌的增殖减少了 3 个对数级，而罗伊氏乳杆菌的生长不受痤疮丙酸杆菌或表皮葡萄球菌的影响。在所检查的罗伊氏乳杆菌菌株中，罗伊氏乳杆菌 KCTC 3679 对痤疮丙酸杆菌和表皮葡萄球菌的生长抑制作用最强，其次是罗伊氏乳杆菌 KCTC 3594 和罗伊氏乳杆菌 KCTC 3678。有趣的是，只有罗伊氏乳杆菌 KCTC 3594 产生了抗菌因子 reuterin。罗伊氏乳杆菌最强的抗菌活性归因于有机酸的产生。总的来说，这些结果表明，罗伊氏乳杆菌可能是一种有用的益生菌制剂，可控制参与痤疮炎症的细菌的生长并预防痤疮。
