Butler Éile, Lundqvist Christoffer, Axelsson Jakob
BioGaia AB, Mobilvägen 10, 223 62 Lund, Sweden.
Faculty of health and society, Department of Health Biomedical, Malmö University, Jan Waldenströms Gata 25, 214 28 Malmö, Sweden.
Microorganisms. 2020 Jul 11;8(7):1026. doi: 10.3390/microorganisms8071026.
Atopic Dermatitis (AD) is a chronically relapsing skin condition characterized by dry, itchy, and inflamed skin where sufferers can frequently be subject to infections. Probiotics are known to be potent immune-modulators, and live DSM 17938 has shown to be anti-inflammatory but also to possess antimicrobial and barrier function properties. This study aimed to investigate and compare two investigational ointment products (topical probiotic and control) for cutaneous acceptability, safety, and efficacy under normal conditions of use, in adult subjects with atopic dermatitis. The products were applied twice daily for 8 weeks, and cutaneous acceptability, SCORAD index, local SCORAD, and adverse events were evaluated after 4 and 8 weeks of treatment. At the end of the observations, it was demonstrated that both the probiotic-containing and probiotic-free ointments were both cutaneously acceptable and safe. It importantly showed a statistically and clinically significant improvement of the SCORAD index and local SCORAD in adult subjects with AD after 4 and 8 weeks of continuous use. In conclusion, we show evidence that the probiotic product, containing live DSM 17938 as an extra ingredient, is safe and promising as a novel topical cosmetic ointment and with further testing could be a standard topical product for the management of atopic dermatitis or other disorders associated with the skin.
特应性皮炎（AD）是一种慢性复发性皮肤病，其特征为皮肤干燥、瘙痒和发炎，患者经常容易受到感染。已知益生菌是强效免疫调节剂，活的DSM 17938已显示出具有抗炎作用，还具有抗菌和屏障功能特性。本研究旨在调查和比较两种研究用软膏产品（局部用益生菌产品和对照产品）在正常使用条件下，对患有特应性皮炎的成年受试者的皮肤可接受性、安全性和有效性。产品每天涂抹两次，持续8周，在治疗4周和8周后评估皮肤可接受性、SCORAD指数、局部SCORAD和不良事件。在观察期结束时，结果表明含益生菌软膏和不含益生菌软膏在皮肤上均可接受且安全。重要的是，在连续使用4周和8周后，患有特应性皮炎的成年受试者的SCORAD指数和局部SCORAD在统计学和临床上均有显著改善。总之，我们有证据表明，含有活的DSM 17938作为额外成分的益生菌产品作为一种新型局部用化妆品软膏是安全且有前景的，经过进一步测试，可能成为治疗特应性皮炎或其他皮肤相关疾病的标准局部用产品。
