Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cereb Cortex. 2013 Mar;23(3):594-603. doi: 10.1093/cercor/bhs043. Epub 2012 Feb 24.
An anticorrelated interaction between the dorsal attention and the default-mode networks has been observed, although how these 2 networks establish such relationship remains elusive. Behavioral studies have reported the emergence of attention and default network-related functions and a preliminary competing relationship between them at early infancy. This study attempted to test the hypothesis--resting-state functional magnetic resonance imaging will demonstrate not only improved network synchronization of the dorsal attention and the default networks, respectively, during the first 2 years of life but also an anticorrelated network interaction pattern between the 2 networks at 1 year which will be further enhanced at 2 years old. Our results demonstrate that both networks start from an isolated region in neonates but evolve to highly synchronized networks at 1 year old. Paralleling the individual network maturation process, the anticorrelated behaviors are absent at birth but become apparent at 1 year and are further enhanced during the second year of life. Our studies elucidate not only the individual maturation process of the dorsal attention and default networks but also offer evidence that the maturation of the individual networks may be needed prior exhibiting the adult-like interaction patterns between the 2 networks.
已观察到背侧注意网络和默认模式网络之间存在反向相关的相互作用，尽管这两个网络如何建立这种关系仍不清楚。行为研究报告称，在婴儿早期，注意和默认网络相关功能出现，并且它们之间存在初步的竞争关系。本研究试图验证假设——静息态功能磁共振成像不仅将证明在生命的前 2 年中，背侧注意网络和默认网络的网络同步性分别得到改善，而且在 1 岁时，这两个网络之间将出现反向相关的网络相互作用模式，并且这种模式在 2 岁时会进一步增强。我们的结果表明，两个网络都从新生儿的孤立区域开始，但在 1 岁时演变成高度同步的网络。与单个网络成熟过程平行，在出生时不存在反向相关行为，但在 1 岁时变得明显，并在生命的第二年进一步增强。我们的研究不仅阐明了背侧注意网络和默认网络的个体成熟过程，还提供了证据表明，在两个网络之间表现出类似成人的相互作用模式之前，个体网络的成熟可能是必要的。
