Vilibic-Cavlek Tatjana, Kucinar Jasmina, Ljubin-Sternak Suncanica, Kolaric Branko
Department of Virology, Croatian national Institute of public Health, Zagreb and School of Medicine University of Zagreb, Zagreb, Croatia.
Hepat Mon. 2011 Dec;11(12):997-9. doi: 10.5812/kowsar.1735143X.756. Epub 2011 Dec 20.
Hepatitis A virus (HAV) has a worldwide distribution, although this distribution tends to be uneven among geographical regions and population groups. The prevalence of anti-HAV antibodies in the general population varies widely among countries. In Europe, the seroprevalence of HAV is reported to range from 32% to 88%.
The aim of this study was to determine the seroprevalence of HAV among the general Croatian population.
During a 2-year period (2008-2009), a total of 791 serum samples were tested for the presence of anti-HAV total (IgM+IgG) and anti-HAV IgM antibodies using an automated enzyme-linked fluorescent assay (Mini Vidas; bioMérieux, Marcy l'Etoile, France).
The overall anti-HAV seroprevalence was 41.6%. The observed difference in the seroprevalence rates among male and female patients was not statistically significant (44% vs. 39.6%, P = 0.218). A marked increase in anti-HAV seropositivity with age was observed (P < 0.001). The seroprevalence did not differ significantly between participants residing in rural regions (45.3%) and those residing in urban regions (40.6%, P = 0.292).
Our results corroborate those of seroprevalence studies in other developed countries. More than half of the Croatian population (59.4%) is susceptible to HAV infection. Older age is an important predictor for being anti-HAV positive.
甲型肝炎病毒（HAV）在全球范围内均有分布，不过这种分布在不同地理区域和人群中往往并不均匀。各国普通人群中抗-HAV抗体的流行率差异很大。在欧洲，据报道HAV的血清阳性率在32%至88%之间。
本研究的目的是确定克罗地亚普通人群中HAV的血清阳性率。
在2年期间（2008 - 2009年），使用自动酶联荧光测定法（Mini Vidas；法国生物梅里埃公司，马西伊图瓦勒）对总共791份血清样本进行抗-HAV总抗体（IgM + IgG）和抗-HAV IgM抗体检测。
抗-HAV总体血清阳性率为41.6%。男性和女性患者血清阳性率的观察差异无统计学意义（44%对39.6%，P = 0.218）。观察到抗-HAV血清阳性率随年龄显著增加（P < 0.001）。居住在农村地区的参与者（45.3%）和居住在城市地区的参与者（40.6%）之间的血清阳性率无显著差异（P = 0.292）。
我们的结果证实了其他发达国家血清阳性率研究的结果。超过一半的克罗地亚人口（59.4%）易感染HAV。年龄较大是抗-HAV阳性的一个重要预测因素。
