Department of Zoology, University of Oxford, Oxford, UK.
Epidemiol Infect. 2012 Dec;140(12):2247-55. doi: 10.1017/S0950268812000192. Epub 2012 Feb 28.
We sought to explain seasonality and other aspects of Campylobacter jejuni epidemiology by integrating population genetic and epidemiological analysis in a large 3-year longitudinal, two-centre, population-based study. Epidemiological information was collected for 1505 isolates, which were multilocus sequence-typed. Analyses compared pathogen population structure between areas, over time, and between clinical presentations. Pooled analysis was performed with published international datasets. Subtype association with virulence was not observed. UK sites had nearly identical C. jejuni populations. A clade formed by ST45 and ST283 clonal complexes showed a summer peak. This clade was common in a Finnish dataset but not in New Zealand and Australian collections, countries with less marked seasonality. The UK, New Zealand and Australian collections were otherwise similar. These findings map to known in-vitro differences of this clade. This identifies a target for studies to elucidate the drivers of the summer peak in human C. jejuni infection.
我们通过在一项为期 3 年的大型纵向、双中心、基于人群的研究中整合群体遗传学和流行病学分析，旨在解释空肠弯曲菌的季节性和其他流行病学特征。为 1505 株分离株收集了流行病学信息，这些分离株进行了多位点序列分型。分析比较了不同地区、不同时间和不同临床表现之间的病原体种群结构。对已发表的国际数据集进行了汇总分析。未观察到亚型与毒力相关。英国各地区空肠弯曲菌种群几乎相同。由 ST45 和 ST283 克隆复合体组成的一个分支显示出夏季高峰。该分支在芬兰的一个数据集很常见，但在新西兰和澳大利亚的采集集中并不常见，这两个国家的季节性不那么明显。英国、新西兰和澳大利亚的采集集则相似。这些发现与该分支的已知体外差异相对应。这确定了一个目标，可用于研究阐明人类空肠弯曲菌感染夏季高峰的驱动因素。
