2-烯丙基苯基糖苷作为糖基供体用于糖偶联。
2-Allylphenyl glycosides as glycosyl donors for sugar coupling.
机构信息
Department of Chemistry, National Tsing Hua University, 101, Sec. 2, Kuang-Fu Road, Hsinchu 300, Taiwan.
出版信息
Carbohydr Res. 2012 May 1;352:197-201. doi: 10.1016/j.carres.2012.01.022. Epub 2012 Feb 7.
PMID:22370177
Abstract
Glycosylations employing 2-allylphenyl glycoside, a new type of stable glycosyl donor, were optimized and explored with a variety of acceptors promoted by ICl/AgOTf. The utility of the protocol was further demonstrated with an efficient synthesis of the disaccharide fragment of bleomycins.
摘要
采用 2-烯丙基苯基糖苷作为新型稳定糖苷供体，对糖苷化反应进行了优化和探索，并通过 ICl/AgOTf 促进了多种受体的反应。该方案的实用性通过高效合成博来霉素的二糖片段得到了进一步证明。
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