免疫功能低下患者接受复杂的联合治疗时，使用出乎意料低剂量的利奈唑胺成功长期治疗脑诺卡菌病。
Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy.
机构信息
Department of Experimental and Clinical Medical Sciences, Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Medical School, University of Udine, Udine, Italy.
出版信息
Antimicrob Agents Chemother. 2012 Jun;56(6):3438-40. doi: 10.1128/AAC.00135-12. Epub 2012 Feb 27.
Abstract
Cerebral nocardiosis is a severe infection that carries the highest mortality rate among all bacterial cerebral abscesses. We report on a case in an immunocompromised patient which was successfully treated with unexpectedly low doses of linezolid. Therapeutic drug monitoring was very helpful in highlighting issues of poor compliance and of drug-drug interactions.
摘要
脑诺卡菌病是一种严重的感染，在所有细菌性脑脓肿中死亡率最高。我们报告了一例免疫功能低下患者的病例，该患者成功地接受了出乎意料低剂量的利奈唑胺治疗。治疗药物监测非常有助于突出药物依从性差和药物相互作用的问题。
相似文献
1
Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy.免疫功能低下患者接受复杂的联合治疗时，使用出乎意料低剂量的利奈唑胺成功长期治疗脑诺卡菌病。
Antimicrob Agents Chemother. 2012 Jun;56(6):3438-40. doi: 10.1128/AAC.00135-12. Epub 2012 Feb 27.
2
Linezolid combined with trimethoprim-sulfamethoxazole therapy for the treatment of disseminated nocardiosis.利奈唑胺联合复方磺胺甲噁唑治疗播散性奴卡菌病。
J Med Microbiol. 2011 Jul;60(Pt 7):1043-1045. doi: 10.1099/jmm.0.018549-0. Epub 2011 Mar 10.
3
[The significance of antibiotic-hypersensitivity syndrome].[抗生素超敏反应综合征的意义]
Enferm Infecc Microbiol Clin. 2011 Aug-Sep;29(7):558-9. doi: 10.1016/j.eimc.2011.03.008. Epub 2011 May 12.
4
Successful treatment of multifoci nocardial brain abscesses: a case report and literature review.多灶性心肌脑脓肿的成功治疗：一例报告及文献综述
Medicine (Baltimore). 2015 May;94(19):e848. doi: 10.1097/MD.0000000000000848.
5
Successful medical treatment of multiple brain abscesses due to Nocardia farcinica in a paediatric renal transplant recipient.一名儿科肾移植受者因鼻疽诺卡菌感染导致多发性脑脓肿的成功医学治疗。
Pediatr Nephrol. 2005 Aug;20(8):1186-8. doi: 10.1007/s00467-005-1978-6. Epub 2005 Jun 10.
6
Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review.弥漫性诺卡菌感染伴重症肌无力患者经利奈唑胺治疗成功：病例报告及文献复习。
J Infect Chemother. 2012 Jun;18(3):390-4. doi: 10.1007/s10156-011-0315-1. Epub 2011 Oct 14.
7
Disseminated Nocardiosis caused by Nocardia concava with acute respiratory failure and central nervous system involvement treated with linezolid.由凹诺卡菌引起的播散性诺卡菌病伴急性呼吸衰竭及中枢神经系统受累，采用利奈唑胺治疗。
Intern Med. 2012;51(23):3281-5. doi: 10.2169/internalmedicine.51.7733. Epub 2012 Dec 1.
8
Listeria monocytogenes meningitis and multiple brain abscesses in an immunocompetent host. Favorable response to combination linezolid-meropenem treatment.免疫功能正常宿主中的单核细胞增生李斯特菌脑膜炎和多发性脑脓肿。对利奈唑胺-美罗培南联合治疗反应良好。
J Chemother. 2006 Jun;18(3):331-3. doi: 10.1179/joc.2006.18.3.331.
9
Clinical experience with linezolid for the treatment of nocardia infection.利奈唑胺治疗诺卡菌感染的临床经验。
Clin Infect Dis. 2003 Feb 1;36(3):313-8. doi: 10.1086/345907. Epub 2003 Jan 13.
10
引用本文的文献
1
Brain Abscesses by Nocardia: An Interesting Case.诺卡菌所致脑脓肿：1例有趣病例
Cureus. 2023 May 11;15(5):e38911. doi: 10.7759/cureus.38911. eCollection 2023 May.
2
Application of therapeutic drug monitoring to the treatment of bacterial central nervous system infection: a scoping review.治疗药物监测在细菌性中枢神经系统感染治疗中的应用：范围综述。
J Antimicrob Chemother. 2022 Nov 28;77(12):3408-3413. doi: 10.1093/jac/dkac332.
3
Clinical Characteristics and Treatment Outcome of Central Nervous System Nocardiosis: A Systematic Review of Reported Cases.中枢神经系统奴卡菌病的临床特征和治疗结局：系统综述报道病例。
Med Princ Pract. 2022;31(4):333-341. doi: 10.1159/000525509. Epub 2022 Jun 14.
4
Orthopaedic Implant-Associated Staphylococcal Infections: A Critical Reappraisal of Unmet Clinical Needs Associated with the Implementation of the Best Antibiotic Choice.骨科植入物相关葡萄球菌感染：对最佳抗生素选择实施过程中未满足的临床需求的批判性重新评估。
Antibiotics (Basel). 2022 Mar 17;11(3):406. doi: 10.3390/antibiotics11030406.
5
Safety and Outcomes of Linezolid Use for Nocardiosis.利奈唑胺用于治疗诺卡菌病的安全性及疗效
Open Forum Infect Dis. 2020 Mar 16;7(4):ofaa090. doi: 10.1093/ofid/ofaa090. eCollection 2020 Apr.
6
A 1 year retrospective audit of quality indicators of clinical pharmacological advice for personalized linezolid dosing: one stone for two birds?利奈唑胺个体化给药临床药学建议质量指标的1年回顾性审计：一石二鸟？
Br J Clin Pharmacol. 2016 Feb;81(2):341-8. doi: 10.1111/bcp.12806. Epub 2015 Dec 5.
7
Successful treatment of multifoci nocardial brain abscesses: a case report and literature review.多灶性心肌脑脓肿的成功治疗：一例报告及文献综述
Medicine (Baltimore). 2015 May;94(19):e848. doi: 10.1097/MD.0000000000000848.
8
How do we use therapeutic drug monitoring to improve outcomes from severe infections in critically ill patients?我们如何利用治疗药物监测来改善重症患者严重感染的治疗效果？
BMC Infect Dis. 2014 Nov 28;14:288. doi: 10.1186/1471-2334-14-288.
9
Nocardiosis: risk factors, clinical characteristics and outcome.诺卡菌病：危险因素、临床特征及预后
Iran Red Crescent Med J. 2013 May;15(5):436-9. doi: 10.5812/ircmj.2384. Epub 2013 May 5.
本文引用的文献
1
Therapeutic drug monitoring of linezolid: a retrospective monocentric analysis.利奈唑胺的治疗药物监测：一项回顾性单中心分析。
Antimicrob Agents Chemother. 2010 Nov;54(11):4605-10. doi: 10.1128/AAC.00177-10. Epub 2010 Aug 23.
2
Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction.肾功能障碍患者因持续高浓度利奈唑胺导致血小板减少和贫血。
J Infect Chemother. 2011 Feb;17(1):70-5. doi: 10.1007/s10156-010-0080-6. Epub 2010 Jun 26.
3
Nocardiosis: updated clinical review and experience at a tertiary center.奴卡菌病：三级中心的最新临床综述和经验。
Infection. 2010 Apr;38(2):89-97. doi: 10.1007/s15010-009-9193-9. Epub 2010 Mar 20.
4
Linezolid: a review of safety and tolerability.利奈唑胺：安全性与耐受性综述
J Infect. 2009 Sep;59 Suppl 1:S59-74. doi: 10.1016/S0163-4453(09)60009-8.
5
Linezolid for the treatment of Nocardia spp. infections.利奈唑胺用于治疗诺卡菌属感染。
Ann Pharmacother. 2007 Oct;41(10):1694-9. doi: 10.1345/aph.1K196. Epub 2007 Sep 4.
6
Linezolid for the treatment of patients with central nervous system infection.利奈唑胺用于治疗中枢神经系统感染患者。
Ann Pharmacother. 2007 Feb;41(2):296-308. doi: 10.1345/aph.1H307. Epub 2007 Feb 6.
7
Serum and cerebrospinal fluid concentrations of linezolid in neurosurgical patients.神经外科患者血清和脑脊液中利奈唑胺的浓度
Antimicrob Agents Chemother. 2006 Dec;50(12):3971-6. doi: 10.1128/AAC.00051-06. Epub 2006 Sep 18.
8
Characterization of beta-adrenoceptor antagonists as substrates and inhibitors of the drug transporter P-glycoprotein.β-肾上腺素能受体拮抗剂作为药物转运体P-糖蛋白的底物和抑制剂的特性研究
Fundam Clin Pharmacol. 2006 Jun;20(3):273-82. doi: 10.1111/j.1472-8206.2006.00408.x.
9
Clinical and laboratory features of the Nocardia spp. based on current molecular taxonomy.基于当前分子分类学的诺卡氏菌属的临床和实验室特征。
Clin Microbiol Rev. 2006 Apr;19(2):259-82. doi: 10.1128/CMR.19.2.259-282.2006.
10
Hyperlactacidemia potentially due to linezolid overexposure in a liver transplant recipient.肝移植受者中高乳酸血症可能归因于利奈唑胺暴露过量。
Clin Infect Dis. 2006 Feb 1;42(3):434-5. doi: 10.1086/499533.
Zotero 插件