Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Harbin Engineering University, Harbin, China.
Dalton Trans. 2012 Apr 21;41(15):4511-6. doi: 10.1039/c2dt11552b. Epub 2012 Feb 29.
A family of mesoporous silica microspheres with fibrous morphology and different particle sizes ranging from about 400 to 900 nm has been successfully synthesized through a facile self-assembly process. The structural, morphological, and textural properties of the samples were well characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), N(2) adsorption/desorption, and thermal gravimetry (TG). The results reveal that this silica-based mesoporous material exhibits excellent physical properties, including a fibrous spherical morphology, good thermal stability, large pore volume, high specific surface area and narrow size distribution. Additionally, the size and textural properties can be tuned by altering the silica precursor/template molar ratio. The formation and the self-assembly evolution process have also been proposed. The obtained materials were further used as a drug delivery carrier to investigate the in vitro drug release properties using doxorubicin (DOX) as a representative model drug. It was found that this kind of silica exhibits good biocompatibility and obvious sustained drug release properties, suggesting its potential application in biological fields.
通过简便的自组装过程，成功合成了具有纤维形态和不同粒径（约 400 至 900nm）的介孔硅微球家族。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、核磁共振（NMR）、傅里叶变换红外光谱（FT-IR）、N2吸附/脱附、热重（TG）对样品的结构、形态和结构性能进行了很好的表征。结果表明，这种基于二氧化硅的介孔材料具有优异的物理性能，包括纤维状球形形态、良好的热稳定性、大孔体积、高比表面积和窄的尺寸分布。此外，可以通过改变硅前体/模板的摩尔比来调节尺寸和结构性能。还提出了形成和自组装演变过程。所得材料进一步用作药物载体，以阿霉素（DOX）为代表模型药物研究体外药物释放性能。结果表明，这种二氧化硅具有良好的生物相容性和明显的持续药物释放性能，表明其在生物领域的潜在应用。
