Department of Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, 3720 BA Bilthoven, the Netherlands.
Vaccine. 2012 Apr 16;30(18):2892-9. doi: 10.1016/j.vaccine.2012.02.030. Epub 2012 Feb 26.
In 2009, the Dutch government advised pregnant women to get vaccinated against influenza A (H1N1). A study was set up to gain insight into vaccination coverage and reasons why pregnant women seek vaccination or not.
We invited 14,529 pregnant women to complete an internet survey on vaccination during pregnancy in general and against 2009 influenza A (H1N1). Differences in background characteristics between unvaccinated and vaccinated women were investigated. Prediction analyses were carried out to determine which survey statement had the greatest impact on vaccination status or intention to get vaccinated during pregnancy.
Of the 2993 included respondents, 63% reported to be vaccinated against 2009 influenza A (H1N1). Vaccination coverage was higher among older birth cohorts, women who had been pregnant before, women with underlying medical conditions, and women who reported no defined 'life philosophy'. Protection of the child (after birth), the government's advice and possible harmful effects of the vaccine for the unborn child had the greatest predictive value for vaccination status. With regards vaccination during future pregnancies, 39% had a positive intention to obtain vaccination and 45% were neutral. The government's advice was the strongest predictor for intention. Furthermore, women expressed concern over lack of sufficient knowledge about vaccine safety.
A considerable number of pregnant women in the Netherlands reported to be vaccinated against 2009 influenza A (H1N1). The challenge for the government in the future will be to provide pregnant women and health care professionals with sufficient and clear information about disease severity and the benefits and safety of vaccination.
2009 年，荷兰政府建议孕妇接种甲型 H1N1 流感疫苗。本研究旨在深入了解孕妇的疫苗接种率以及她们选择接种或不接种疫苗的原因。
我们邀请了 14529 名孕妇参与一项关于一般孕期接种疫苗和接种 2009 年甲型 H1N1 流感疫苗的互联网调查。调查了未接种和已接种疫苗孕妇的背景特征差异。进行预测分析，以确定哪些调查陈述对疫苗接种状况或孕期接种疫苗的意愿影响最大。
在纳入的 2993 名受访者中，63%的人报告接种了 2009 年甲型 H1N1 流感疫苗。较年长的出生队列、有过怀孕经历的妇女、患有基础疾病的妇女和报告没有明确“生活哲学”的妇女接种率更高。保护孩子（出生后）、政府的建议以及疫苗对胎儿可能产生的有害影响对疫苗接种状况具有最大的预测价值。至于未来怀孕时的接种，39%的人有积极接种的意愿，45%的人持中立态度。政府的建议是影响意愿的最强因素。此外，妇女对疫苗安全性的知识不足表示担忧。
荷兰相当多的孕妇报告接种了 2009 年甲型 H1N1 流感疫苗。政府未来的挑战将是向孕妇和医疗保健专业人员提供关于疾病严重程度以及疫苗接种的益处和安全性的充分和明确信息。
