Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Pharmacoepidemiol Drug Saf. 2012 Jun;21(6):659-65. doi: 10.1002/pds.3207. Epub 2012 Feb 28.
When using electronic medical record data to study drug use, hospitalizations are markers of severe outcomes. To identify events within a specified time window, it is important to validate hospitalization diagnoses and dates. Our objective was to validate pneumonia hospitalizations and their dates identified using hospitalization codes in The Health Improvement Network (THIN), a UK primary care electronic medical record.
This cross-sectional study used a cohort of THIN adult visits for acute nonspecific respiratory infections from June 1985 to August 2006. Pneumonia hospitalizations within 30 days after the visit were identified using THIN diagnosis and hospitalization codes; 60 participants were randomly selected for validation. Patients' general practitioners (GPs) returned de-identified hospital summaries and consultants' letters regarding overnight hospitalizations within a 180-day window around the THIN hospitalization. Positive predictive value (PPV) was the number of GP-validated hospitalizations divided by THIN documented hospitalizations.
GPs returned 59 of 60 patient records; 52 had confirmed hospitalizations. PPV of THIN hospitalization documentation was 88% (95%CI = 77-95). One admission was not for pneumonia; PPV of THIN-documented pneumonia admission was 86% (95%CI = 75-94). Of 52 valid THIN hospitalizations, 50 were actually admitted within 14 days of the documented THIN date (range = -2 to +18). The absolute median difference between THIN and validated admission dates was +0.5 days, and the absolute mean difference was +3.1 days. In 16 of 52 admitted patients, the THIN admission date was the actual discharge date.
THIN hospitalization codes performed well in identifying acute pneumonia hospitalizations and their timing. Admission date validity might be better for conditions associated with shorter versus longer hospitalizations.
在使用电子病历数据研究药物使用情况时,住院是严重后果的标志。为了在指定的时间窗口内识别事件,验证住院诊断和日期非常重要。我们的目的是验证使用英国初级保健电子病历 The Health Improvement Network(THIN)中的住院代码识别的肺炎住院和住院日期。
这项横断面研究使用了 1985 年 6 月至 2006 年 8 月间 THIN 成人急性非特异性呼吸道感染就诊的队列。使用 THIN 诊断和住院代码在就诊后 30 天内识别肺炎住院;随机选择 60 名参与者进行验证。患者的全科医生(GP)返回了关于在 THIN 住院后 180 天内夜间住院的匿名住院记录和顾问信件。阳性预测值(PPV)是经 GP 验证的住院人数与 THIN 记录的住院人数之比。
GP 返还了 60 份患者记录中的 59 份;其中 52 份有确诊住院。THIN 住院记录文件的 PPV 为 88%(95%CI=77-95)。有 1 次入院不是肺炎;THIN 记录的肺炎入院的 PPV 为 86%(95%CI=75-94)。在 52 份经验证的 THIN 住院中,有 50 份实际上是在记录的 THIN 日期的 14 天内入院(范围=-2 至+18)。THIN 和验证的入院日期之间的绝对中位数差异为+0.5 天,绝对平均值差异为+3.1 天。在 52 名入院患者中,有 16 名患者的 THIN 入院日期是实际出院日期。
THIN 住院代码在识别急性肺炎住院及其时间方面表现良好。入院日期的有效性可能更适合与较短住院时间相关的疾病。