DeRossi Rafael, Pompermeyer Cassio Tadeu Dias, Silva-Neto Amadeu Batista, Barros Andrea Lantieri Correa de, Jardim Paulo Henrique de Affonseca, Frazílio Fabrício Oliveira
Department of Veterinary Medicine, Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, UFMS, Mato Grosso do Sul, Brazil.
Acta Cir Bras. 2012 Feb;27(2):137-43. doi: 10.1590/s0102-86502012000200007.
To determine the analgesic, motor, sedation and systemic effects of lumbosacral epidural magnesium sulphate added to ketamine in the sheep.
Six healthy adult male mixed-breed sheep; weighing 43 ± 5 kg and aged 20-36 months. Each sheep underwent three treatments, at least 2 weeks apart, via epidural injection: (1) ketamine (KE; 2.5 mg/kg), (2) magnesium sulphate (MG; 100 mg), and (3) KE + MG (KEMG; 2.5 mg/kg + 100 mg, respectively). Epidural injections were administered through the lumbosacral space. Analgesia, motor block, sedation, cardiovascular effects, respiratory rate, skin temperature, and rectal temperature were evaluated before (baseline) and after drug administration as needed.
The duration of analgesia with the lumbosacral epidural KEMG combination was 115 ± 17 min (mean ± SD), that is, more than twice that obtained with KE (41 ± 7 min) or MG (29 ± 5 min) alone. KE and KEMG used in this experiment induced severe ataxia. The heart rate and arterial blood pressures changes were no statistical difference in these clinically health sheep.
The dose of magnesium sulphate to lumbosacral epidural ketamine in sheep is feasible, and can be used in procedures analgesics in sheep.
确定在绵羊中，腰段硬膜外给予硫酸镁并联合氯胺酮后的镇痛、运动、镇静及全身效应。
选用6只健康成年雄性杂种绵羊，体重43±5千克，年龄20 - 36个月。每只绵羊至少间隔2周接受3次经硬膜外注射的治疗：（1）氯胺酮（KE；2.5毫克/千克），（2）硫酸镁（MG；100毫克），（3）KE + MG（KEMG；分别为2.5毫克/千克 + 100毫克）。硬膜外注射通过腰段骶部间隙进行。在给药前（基线）及必要时给药后评估镇痛、运动阻滞、镇静、心血管效应、呼吸频率、皮肤温度和直肠温度。
腰段硬膜外KEMG联合用药的镇痛持续时间为115±17分钟（均值±标准差），即比单独使用KE（41±7分钟）或MG（29±5分钟）获得的镇痛持续时间长两倍多。本实验中使用的KE和KEMG导致严重共济失调。在这些临床健康的绵羊中，心率和动脉血压变化无统计学差异。
绵羊腰段硬膜外给予氯胺酮时添加硫酸镁的剂量是可行的，可用于绵羊手术镇痛。
