DeRossi R, Pagliosa R C, de Carvalho A Q, Macedo G G, Hermeto L C
Department of Veterinary Medicine-Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Department of Animal Reproduction, Faculty of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Vet Rec. 2017 Jan 28;180(4):96. doi: 10.1136/vr.103860. Epub 2016 Oct 25.
Six healthy, female, mixed-breed 18-24-month-old sheep weighing 30-48 kg were submitted to lumbosacral epidural bupivacaine in combination with either methadone or fentanyl. Epidural catheters were placed in six sheep that were given three treatments: (Bup) bupivacaine (0.5 mg/kg) alone; (BupMet) bupivacaine (0.25 mg/kg) plus methadone (0.3 mg/kg); and (BupFent) bupivacaine (0.25 mg/kg) plus fentanyl (0.002 mg/kg). Haemodynamic variables, respiratory rate, rectal temperature, analgesia by applying a standard painful stimulus, motor block and sedative scores were compared among the three treatments. These parameters were determined before epidural administration and at 5, 10, 20, 30, 60, 90, 120 minutes after treatment administration, and then every 60 minutes thereafter until the end of analgesic effect. Parametrical data were analysed by proc glimmix (SAS) for repeated measures on time and means tested by ls-means. Non-parametrical data were analysed by Fisher's exact test. Duration of analgesia was longer with BupMet (240 minutes) compared with BupFent (180 minutes; P=0.0127), but BupMet was similar to Bup (240 minutes). Both treatments with opioids produced moderate motor blockade. BupMet and BupFent produced mild sedation. Only treatment with bupivacaine alone induced cardiovascular and respiratory rate changes that stayed within acceptable limits.
六只健康的、18至24月龄的雌性混种绵羊，体重30至48千克，接受了腰荐部硬膜外布比卡因联合美沙酮或芬太尼的治疗。将硬膜外导管置入六只绵羊体内，对其进行三种治疗：（布比）单独使用布比卡因（0.5毫克/千克）；（布比美）布比卡因（0.25毫克/千克）加美沙酮（0.3毫克/千克）；（布比芬）布比卡因（0.25毫克/千克）加芬太尼（0.002毫克/千克）。比较了三种治疗之间的血流动力学变量、呼吸频率、直肠温度、通过施加标准疼痛刺激评估的镇痛效果、运动阻滞和镇静评分。这些参数在硬膜外给药前以及给药后5、10、20、30、60、90、120分钟测定，此后每60分钟测定一次，直至镇痛效果结束。参数数据通过proc glimmix（SAS）进行重复测量时间分析，并通过ls-means检验均值。非参数数据通过Fisher精确检验进行分析。与布比芬（180分钟；P=0.0127）相比，布比美组的镇痛持续时间更长（240分钟），但布比美组与布比组（240分钟）相似。两种使用阿片类药物的治疗均产生中度运动阻滞。布比美组和布比芬组产生轻度镇静。仅单独使用布比卡因的治疗引起的心血管和呼吸频率变化在可接受范围内。
