Kowalczyk Dariusz, Wiecek Jacek, Guzikowski Wojciech, Ośko Andrzej
Samodzielny Specjalistyczny Zespół Opieki Zdrowotnej nad Matka i Dzieckiem w Opolu, Polska.
Ginekol Pol. 2011 Oct;82(10):738-42.
Analysis of the course of pregnancy and labor in patients qualified for the prenatal diagnostic tests program in Opole Region.
2513 pregnant women participated in the program. There were 1763 (70.1%) patients above 35 years of age, out of whom 515 women (20.5%) were qualified for amniocentesis and 394 of them (15.6%) decided to undergo the test. Within the group of patients who underwent amniocentesis, 39 karyotypes (9.8%) were found. Analysis of the number of amniocenteses carried out and the number of detected fetal defects showed that initially the number of invasive tests was rising. However since 2007, i.e. since the introduction of biochemical diagnostic tests based on Kryptor technology a significant decrease of amniocenteses tests has been observed, while the rate of detected chromosome aberrations in fetuses has not changed. The course of pregnancy and labor in patients above 35 years of age, who gave birth to children in Gynecology and Obstetrics Hospital in Opole, has also been analyzed. The investigated group comprised 106 patients who underwent amniocentesis, and 138 patients who did not consent to having the invasive test. Apart from a small difference in average birth weight, the analysis of infant condition and their biophysical parameters after the labor has not shown any significant differences. In both groups gestational diabetes was the most frequent disease, and statistically it was diagnosed more often in patients who had not undergone amniocentesis. No statistically significant differences in the frequency of occurrence of other pregnancy complications have been found.
分析奥波莱地区符合产前诊断测试项目的患者的妊娠和分娩过程。
2513名孕妇参与了该项目。其中1763名（70.1%）患者年龄在35岁以上，其中515名女性（20.5%）符合羊膜穿刺术条件，394名（15.6%）决定接受该检查。在接受羊膜穿刺术的患者组中，发现39例核型（9.8%）。对羊膜穿刺术的实施次数和检测到的胎儿缺陷数量进行分析表明，最初侵入性检查的数量在增加。然而，自2007年以来，即自引入基于Kryptor技术的生化诊断测试以来，羊膜穿刺术的检查数量显著减少，而胎儿染色体畸变的检出率并未改变。还分析了在奥波莱妇产科医院分娩的35岁以上患者的妊娠和分娩过程。研究组包括106名接受羊膜穿刺术的患者和138名不同意进行侵入性检查的患者。除平均出生体重存在微小差异外，对分娩后婴儿状况及其生物物理参数的分析未显示任何显著差异。两组中妊娠糖尿病都是最常见的疾病，从统计学上看，未接受羊膜穿刺术的患者中该疾病的诊断更为频繁。在其他妊娠并发症的发生率方面未发现统计学上的显著差异。
