Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Vaccine. 2012 Apr 19;30(19):2999-3002. doi: 10.1016/j.vaccine.2012.02.035. Epub 2012 Feb 27.
To estimate the mumps vaccine effectiveness (VE) during a large genotype D mumps outbreak, we conducted a cross-sectional study in eight primary schools and associated households in the Netherlands. Questionnaires were used to collect information on the occurrence of mumps. Multivariate analyses were used to estimate VE. Among schoolchildren we estimated the VE against mumps. Among household contacts where the schoolchild was the index case we estimated the VE against mumps and against mumps infectiousness. In total 1175 children and 2281 household contacts participated in the study. The mumps attack rate among schoolchildren was 17%. The mumps VE in schoolchildren was 92% [95% confidence interval (CI) 83-96%] and 93% [85-97%] for one and two doses of the measles, mumps, rubella (MMR) vaccine, respectively. The adjusted mumps VE among household contacts was 67% [65-95%] and 11% [-4 to 88%] against mumps and mumps infectiousness, respectively. Our study indicates that the mumps component of the MMR vaccine offered adequate protection against mumps among schoolchildren. The relatively low VE among household contacts is of concern.
为了评估在大规模基因型 D 流行性腮腺炎暴发期间腮腺炎疫苗的有效性 (VE)，我们在荷兰的八所小学及其相关家庭中进行了一项横断面研究。使用问卷收集有关腮腺炎发生的信息。使用多变量分析来估计 VE。我们估计了在校儿童中针对腮腺炎的 VE。对于作为索引病例的在校儿童的家庭接触者，我们估计了针对腮腺炎和腮腺炎传染性的 VE。共有 1175 名儿童和 2281 名家庭接触者参加了这项研究。在校儿童的腮腺炎发病率为 17%。在校儿童的腮腺炎 VE 分别为 92%（95%置信区间 83-96%）和 93%（85-97%），分别为一剂和两剂麻疹、腮腺炎、风疹（MMR）疫苗。家庭接触者的调整后腮腺炎 VE 分别为 67%（65-95%）和 11%（-4 至 88%），分别针对腮腺炎和腮腺炎传染性。我们的研究表明，MMR 疫苗中的腮腺炎成分对在校儿童中的腮腺炎提供了充分的保护。家庭接触者中相对较低的 VE 令人担忧。
