Kinesiology Department, California Polytechnic State University, San Luis Obispo, California 93407, USA.
J Appl Physiol (1985). 2012 May;112(9):1612-9. doi: 10.1152/japplphysiol.01365.2011. Epub 2012 Mar 1.
Acute exercise suppresses ad libitum energy intake, but little is known about the effects of exercise on food reward brain regions. After an overnight fast, 30 (17 men, 13 women), healthy, habitually active (age = 22.2 ± 0.7 yr, body mass index = 23.6 ± 0.4 kg/m(2), Vo(2peak) = 44.2 ± 1.5 ml·kg(-1)·min(-1)) individuals completed 60 min of exercise on a cycle ergometer or 60 min of rest (no-exercise) in a counterbalanced, crossover fashion. After each condition, blood oxygen level-dependent responses to high-energy food, low-energy food, and control visual cues, were measured by functional magnetic resonance imaging. Exercise, compared with no-exercise, significantly (P < 0.005) reduced the neuronal response to food (high and low food) cues vs. control cues in the insula (-0.37 ± 0.13 vs. +0.07 ± 0.18%), putamen (-0.39 ± 0.10 vs. -0.10 ± 0.09%), and rolandic operculum (-0.37 ± 0.17 vs. 0.17 ± 0.12%). Exercise alone significantly (P < 0.005) reduced the neuronal response to high food vs. control and low food vs. control cues in the inferior orbitofrontal cortex (-0.94 ± 0.33%), insula (-0.37 ± 0.13%), and putamen (-0.41 ± 0.10%). No-exercise alone significantly (P < 0.005) reduced the neuronal response to high vs. control and low vs. control cues in the middle (-0.47 ± 0.15%) and inferior occipital gyrus (-1.00 ± 0.23%). Exercise reduced neuronal responses in brain regions consistent with reduced pleasure of food, reduced incentive motivation to eat, and reduced anticipation and consumption of food. Reduced neuronal response in these food reward brain regions after exercise is in line with the paradigm that acute exercise suppresses subsequent energy intake.
急性运动抑制随意能量摄入，但对于运动对食物奖励脑区的影响知之甚少。在禁食过夜后，30 名（17 名男性，13 名女性）健康、习惯性活跃（年龄=22.2±0.7 岁，体重指数=23.6±0.4kg/m(2)，Vo(2peak)=44.2±1.5ml·kg(-1)·min(-1))个体以交叉平衡的方式在自行车测力计上进行 60 分钟的运动或 60 分钟的休息（无运动）。在每种情况下之后，通过功能磁共振成像测量高能量食物、低能量食物和对照视觉线索对血液含氧量水平的反应。与无运动相比，运动显著（P < 0.005）降低了岛叶（-0.37±0.13 对+0.07±0.18%）、壳核（-0.39±0.10 对-0.10±0.09%）和 Rolandic 脑岛（-0.37±0.17 对 0.17±0.12%）中食物（高和低食物）线索与对照线索的神经元反应。单独运动还显著（P < 0.005）降低了下眶额皮质（-0.94±0.33%）、岛叶（-0.37±0.13%）和壳核（-0.41±0.10%）中高食物与对照和低食物与对照线索的神经元反应。无运动单独显著（P < 0.005）降低了中（-0.47±0.15%）和下枕叶（-1.00±0.23%）中高与对照和低与对照线索的神经元反应。运动降低了与食物愉悦感降低、进食激励动机降低以及食物预期和消耗降低一致的脑区的神经元反应。运动后这些食物奖励脑区的神经元反应降低与急性运动抑制随后的能量摄入模式一致。
