The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011, People's Republic of China.
J Nat Prod. 2014 Oct 24;77(10):2316-20. doi: 10.1021/np500398m. Epub 2014 Oct 9.
Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of AMP-activated protein kinase (AMPK). Also, this is the first report of compounds 4 and 6 from a natural source.
从黑种草（Nigella sativa，黑孜然）种子的脱脂提取物中分离得到了 6 种罕见的天然吲哚型生物碱，包括 2 种新化合物，17-O-(β-d-吡喃葡萄糖基)-4-O-甲基黑麦灵碱（1）和黑麦灵碱（2），以及 4 种已知化合物（3-6）。17-O-(β-d-吡喃葡萄糖基)-4-O-甲基黑麦灵碱（1）通过激活 AMP 激活的蛋白激酶（AMPK）增加肝细胞（HepG2 细胞）的葡萄糖消耗。此外，这是化合物 4 和 6 首次从天然来源中报道。
