Gallagher Cathal T, Assi Sulaf, Stair Jacqueline L, Fergus Suzanne, Corazza Ornella, Corkery John M, Schifano Fabrizio
School of Pharmacy, University of Hertfordshire, Hatfield, Hertfordshire, UK.
Hum Psychopharmacol. 2012 Mar;27(2):106-12. doi: 10.1002/hup.1255.
The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was banned in the UK in April 2010, and almost immediately, MDAI was widely advertised as a legal alternative. This paper provides both an overview of the current state of knowledge of MDAI and a critical analysis of online available information relating to its psychoactive effects, adverse reactions and use in combination with other drugs.
The literature on MDAI was searched in three databases: PsycInfo, PubMed and MedScape. Once the availability of information on MDAI was identified within these websites, further specific searches were carried out for narratives focusing on the nature of its effects on users, motivations behind its recreational use and possible trends of misuse, and any other relevant information.
Internet-sourced products have been shown variously to contain mephedrone, and mixed compositions of inorganic substances, while containing no MDAI. Numbers of Internet searches have been considerably higher in the UK compared with Germany and the US.
Better international collaboration levels may be needed to tackle the novel and fast growing phenomenon of novel psychoactive drug availability from the web.
全合成的“合法兴奋剂”5,6 - 亚甲基二氧基 - 2 - 氨基茚满（MDAI）是3,4 - 亚甲基二氧基甲基苯丙胺的类似物。尽管它在20世纪90年代就已研制出来，但直到2010年才被广泛滥用。然而，甲氧麻黄酮于2010年4月在英国被禁用，几乎与此同时，MDAI作为一种合法替代品被广泛宣传。本文既概述了目前关于MDAI的知识现状，又对网上可获取的有关其精神活性作用、不良反应以及与其他药物联合使用的信息进行了批判性分析。
在三个数据库中搜索关于MDAI的文献：PsycInfo、PubMed和MedScape。一旦在这些网站上确定了有关MDAI的信息，就进一步进行特定搜索，以查找侧重于其对使用者影响的性质、娱乐性使用背后的动机以及可能的滥用趋势的叙述，以及任何其他相关信息。
网络来源的产品已被证明不同程度地含有甲氧麻黄酮以及无机物质的混合成分，而不含MDAI。与德国和美国相比，英国的网络搜索量要高得多。
可能需要更好的国际合作水平来应对从网络获取新型精神活性药物这一新颖且快速增长的现象。
