Stephen Zachary R, Kievit Forrest M, Zhang Miqin
Department of Materials Science and Engineering, University of Washington Seattle, WA 98195 USA.
Mater Today (Kidlington). 2011 Jul;14(7-8):330-338. doi: 10.1016/S1369-7021(11)70163-8.
Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. Iron oxide nanoparticles (SPIONs) in particular have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties of easy modification for improved in vivo kinetics and multifunctionality. This review discusses the basics of MR imaging, the origin of SPION's unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION's imaging characteristics, and an outlook on the translational potential of SPIONs.
纳米技术为科学家们提供了新工具，用于开发用于疾病检测和诊断的先进材料。特别是氧化铁纳米颗粒（SPIONs），由于其具有良好的超顺磁性、生物可降解性以及易于修饰的表面特性，从而改善体内动力学和多功能性，因此已被广泛研究作为新型磁共振成像（MRI）造影剂。本文综述了磁共振成像的基础知识、SPION独特磁性的起源、用于检测SPION的MRI采集方法的最新进展、改善SPION成像特性的合成及合成后处理过程，以及对SPION转化潜力的展望。
