Iida Tadayuki, Domoto Tokio, Takigawa Atsushi, Nakamura Satoru, Kato Yoji, Togo Masanori, Chikamura Chiho, Harada Toshihide, Ishizaki Fumiko, Ono Yuichiro
Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Hiroshima J Med Sci. 2011 Dec;60(4):71-8.
We conducted a survey of 111 healthy middle-aged and older women, aged 40 to 80 years, to elucidate the relationships between blood leptin and adiponectin levels and bone mineral density (BMD) in September 2008. We examined the associations between the blood levels of these adipocytokines and the lumbar spine (L2-L4), left femoral, and distal forearm BMD after adjustment for the age and body fat percentage. No correlation was observed between leptin and the BMD. This is presumably due to the fact that the influence of menopause, age, duration of postmenopausal period, and body fat percentage on the BMD is greater than that of leptin levels in healthy women. The adiponectin levels were significantly correlated negatively with the lumbar spine and femoral BMD in premenopausal women, and with forearm BMD in postmenopausal women, regardless of adjustment for age and body fat percentage. It seems likely that adiponectin influences the BMD at different skeletal sites in pre- and postmenopausal women.
2008年9月，我们对111名年龄在40至80岁之间的健康中老年女性进行了一项调查，以阐明血液中瘦素和脂联素水平与骨密度（BMD）之间的关系。在对年龄和体脂百分比进行调整后，我们研究了这些脂肪细胞因子的血液水平与腰椎（L2-L4）、左股骨和远端前臂骨密度之间的关联。未观察到瘦素与骨密度之间存在相关性。这可能是由于在健康女性中，更年期、年龄、绝经后持续时间和体脂百分比对骨密度的影响大于瘦素水平的影响。无论是否对年龄和体脂百分比进行调整，脂联素水平在绝经前女性中与腰椎和股骨骨密度呈显著负相关，在绝经后女性中与前臂骨密度呈显著负相关。脂联素似乎在绝经前和绝经后女性的不同骨骼部位影响骨密度。
