Vaarala O, Salo E, Pelkonen P, Palosuo T, Aho K
National Public Health Institute, Helsinki, Finland.
Acta Paediatr Scand. 1990 Aug-Sep;79(8-9):804-9. doi: 10.1111/j.1651-2227.1990.tb11558.x.
Antibodies against cardiolipin are formed in many different infectious diseases, and high levels are associated with susceptibility to thrombosis, especially in patients with systemic lupus erythematosus. In view of the postulated infectious etiology of Kawasaki disease an its association with thrombosis, we have studied the occurrence of anticardiolipin antibodies in this disease. Serial serum specimens from 36 patients were tested, using a solid-phase enzyme immunoassay. A change of at least 0.3 optical density units between two consecutive specimens for at least one immunoglobulin class was observed in 47% of cases. Peak levels occurred one to two weeks after the onset of symptoms. Four patients developed coronary artery aneurysms, and they all showed a clear anticardiolipin response. Anticardiolipin antibodies might be one factor contributing to coagulation abnormalities in patients with Kawasaki disease.
抗心磷脂抗体在许多不同的感染性疾病中形成，其高水平与血栓形成易感性相关，尤其是在系统性红斑狼疮患者中。鉴于川崎病假定的感染病因及其与血栓形成的关联，我们研究了该疾病中抗心磷脂抗体的发生情况。使用固相酶免疫测定法检测了36例患者的系列血清标本。47%的病例中观察到至少一种免疫球蛋白类别在两个连续标本之间光密度单位至少变化0.3。峰值水平出现在症状发作后一至两周。4例患者发生冠状动脉瘤，他们均表现出明显的抗心磷脂反应。抗心磷脂抗体可能是导致川崎病患者凝血异常的因素之一。
