新型双恶唑啉配体实现了对乙烯基芳烃的对映选择性电催化氰基官能化反应。
New Bisoxazoline Ligands Enable Enantioselective Electrocatalytic Cyanofunctionalization of Vinylarenes.
机构信息
Department of Chemistry and Chemical Biology , Cornell University , Ithaca , New York 14853 , United States.
出版信息
J Am Chem Soc. 2019 Sep 18;141(37):14480-14485. doi: 10.1021/jacs.9b03296. Epub 2019 Sep 9.
Abstract
In contrast to the rapid growth of synthetic electrochemistry in recent years, enantioselective catalytic methods powered by electricity remain rare. In this work, we report the development of a highly enantioselective method for the electrochemical cyanophosphinoylation of vinylarenes. A new family of serine-derived chiral bisoxazolines with ancillary coordination sites were identified as optimal ligands.
摘要
与近年来合成电化学的快速发展形成鲜明对比的是，由电力驱动的对映选择性催化方法仍然很少。在这项工作中，我们报告了一种高对映选择性的电化学氰膦酰化乙烯基芳烃的方法。确定了一系列新的丝氨酸衍生的手性双恶唑啉作为最佳配体，这些配体具有辅助配位位点。
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