a Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
Nat Prod Res. 2013;27(3):201-7. doi: 10.1080/14786419.2012.666746. Epub 2012 Mar 7.
A systematic phytochemical investigation of the aerial parts of Dracocephalum moldavica led to the isolation of 1 new and 16 known compounds. Based on spectroscopic analyses, the new compound was elucidated as a flavonoid glycoside, acacetin-7-O-(4″-acetyl)-glucopyranoside (1). The 16 known compounds were identified as: 9 flavonoids (2-10), 2 lignans (11-12), 4 triterpeniods (13-16) and 1 menthane-type monoterpenoid (17). All the 17 compounds were reported for the first time from D. moldavica. Compound 1 exhibited mild radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Although compound 17, named as citrylidene malonic acid, was a known compound, it possessed an uncommon tricyclic dilactone skeleton, the structure was secured by X-ray crystallography. In addition, compound 17 was tested for cytotoxic activity against A549 cell line, only weak cytotoxicity was shown.
对Dracocephalum moldavica 的地上部分进行系统的植物化学研究，分离得到了 1 个新化合物和 16 个已知化合物。根据光谱分析，新化合物被确定为黄酮类糖苷，即 acacetin-7-O-(4″-acetyl)-glucopyranoside（1）。16 个已知化合物分别鉴定为：9 个黄酮类化合物（2-10）、2 个木脂素（11-12）、4 个三萜类化合物（13-16）和 1 个薄荷烷型单萜（17）。所有这 17 种化合物均首次从 D. moldavica 中分离得到。化合物 1 对 2,2-二苯基-1-苦基肼基（DPPH）具有温和的自由基清除活性。尽管化合物 17，命名为 citrylidene malonic acid，是一种已知的化合物，但它具有不常见的三环二内酯骨架，其结构通过 X 射线晶体学确定。此外，化合物 17 对 A549 细胞系的细胞毒性活性进行了测试，仅显示出微弱的细胞毒性。
