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铑/铜催化苯并咪唑与内炔的环化反应：通过顺序 C-H 和 C-N 断裂合成茚酮。

Rhodium/copper-catalyzed annulation of benzimides with internal alkynes: indenone synthesis through sequential C-H and C-N cleavage.

机构信息

Beijing National Laboratory of Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, China.

出版信息

Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3948-52. doi: 10.1002/anie.201200271. Epub 2012 Mar 6.

DOI:10.1002/anie.201200271
PMID:22396146
Abstract

Doubled up: a rhodium(III)/copper(II) system co-catalyzes the annulation of benzimides with internal alkynes for the synthesis of indenones (see scheme; Cp*=C(5) Me(5)). The reaction involves an uncommon nucleophilic addition of a transition-metal-carbon bond to an imide moiety. This novel reaction provides a facile route to synthesize indenones from readily available benzimides and internal alkynes.

摘要

双重协同作用

铑(III)/铜(II)体系共同催化苯并咪唑与内部炔烃的环化反应，合成茚酮（见方案；Cp*=C(5) Me(5)）。该反应涉及过渡金属-碳键对酰亚胺部分的罕见亲核加成。这种新颖的反应为从易得的苯并咪唑和内部炔烃合成茚酮提供了一条简便的途径。

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