通过 Cu(OAc)2 氧化和 Rh(III)催化的 N-环化序列反应，由烯丙基胺和炔烃合成吡啶。
Pyridine synthesis by reactions of allyl amines and alkynes proceeding through a Cu(OAc)2 oxidation and Rh(III)-catalyzed N-annulation sequence.
机构信息
Department of Chemistry, Yonsei University, 50 Yonseiro, Seodaemun-gu, Seoul 120-749, Korea.
出版信息
Chem Commun (Camb). 2012 Nov 28;48(92):11334-6. doi: 10.1039/c2cc36699a.
PMID:23069867
Abstract
A new methodology has been developed for the synthesis of pyridines from allyl amines and alkynes, which involves sequential Cu(II)-promoted dehydrogenation of the allylamine and Rh(III)-catalyzed N-annulation of the resulting α,β-unsaturated imine and alkyne.
摘要
现已开发出一种从烯丙基胺和炔烃合成吡啶的新方法，该方法涉及铜(II)促进的烯丙胺脱氢和 Rh(III)催化的生成的α,β-不饱和亚胺和炔烃的 N-环化的顺序反应。
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