Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
PLoS One. 2012;7(3):e31926. doi: 10.1371/journal.pone.0031926. Epub 2012 Mar 1.
The C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production. Oxidase is a major source of the superoxide anion that contributes to individual components of metabolic syndrome. We examined the relationship of the C242T polymorphism with the prevalence of metabolic syndrome in a Chinese population, taking account of consumed cigarette amounts.
METHODOLOGY/PRINCIPAL FINDINGS: In 870 participants, we collected biomarkers related to metabolic syndrome and detailed history of smoking and genotyped the C242T polymorphisms. After adjustment for covariates, the CT/TT genotypes were associated with a lower risk of metabolic syndrome (P = 0.0008). The odds of having metabolic syndrome in the CT/TT participants were 0.439 (95%CI: 0.265, 0.726), while for CC participants the odds were 1.110 (95%CI: 0.904, 1.362). There was significant (P = 0.014) interaction between the C242T polymorphism and smoking status in relation to the prevalence of metabolic syndrome. For smokers who smoke no less than 25 pack-years, those with CT/TT genotypes had lower risk of metabolic syndrome as compared with CC polymorphism carriers (P = 0.015). In the multiple regression analysis, the CT/TT genotypes were significantly associated with lower serum concentration of triglycerides both in all subjects and smokers; furthermore, the CT/TT genotypes were also related to smaller waist circumference in smokers.
Our study suggests that the C242T gene polymorphism is indeed related to the prevalence of metabolic syndrome and smoking dose might modify this association.
CYBA 基因的 C242T 多态性编码 NADPH 氧化酶的 p22phox，该基因多态性可调节超氧化物的产生。氧化酶是超氧阴离子的主要来源，超氧阴离子是代谢综合征各组成部分的一个贡献因素。我们研究了 C242T 多态性与中国人群代谢综合征患病率之间的关系，同时考虑了吸烟量。
方法/主要发现：在 870 名参与者中，我们收集了与代谢综合征相关的生物标志物和吸烟的详细病史，并对 C242T 多态性进行了基因分型。调整了协变量后，CT/TT 基因型与代谢综合征的风险降低相关（P=0.0008）。CT/TT 基因型的参与者患代谢综合征的几率为 0.439（95%CI：0.265，0.726），而 CC 基因型的参与者为 1.110（95%CI：0.904，1.362）。C242T 多态性与吸烟状态之间存在显著的交互作用（P=0.014），与代谢综合征的患病率有关。对于吸烟量不少于 25 包年的吸烟者，与 CC 多态性携带者相比，CT/TT 基因型的代谢综合征风险较低（P=0.015）。在多元回归分析中，CT/TT 基因型与所有受试者和吸烟者的血清甘油三酯浓度降低显著相关；此外，CT/TT 基因型也与吸烟者的腰围减小有关。
我们的研究表明，C242T 基因多态性确实与代谢综合征的患病率有关，吸烟量可能会改变这种关联。
