衰老遗传学与衰老。
Aging genetics and aging.
机构信息
Fundación ASTURCOR, Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Av. Julian Clavería s/n, 33006 Oviedo, Spain.
出版信息
Aging Dis. 2011 Jun;2(3):186-95. Epub 2011 Apr 28.
Abstract
The process of aging refers to the decay of an organism's structure and function, in which molecular and cellular modifications can have various effects at the individual level over the course of a lifetime. The accumulation of molecular errors that compromise adult stem cell functions occurs because of genetic and epigenetic interactions and depends on hereditary, environmental, and stochastic factors. Here we review the known genetic factors involved in aging.
摘要
衰老过程是指生物体结构和功能的衰退，在一生中，个体水平上的分子和细胞改变会产生各种影响。由于遗传和表观遗传相互作用，导致成年干细胞功能受损的分子错误积累，这取决于遗传、环境和随机因素。在这里，我们回顾了已知与衰老相关的遗传因素。
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