Valio Ltd, R&D, P.O. Box 30, 00039 Valio, Finland.
Food Funct. 2012 Jun;3(6):621-7. doi: 10.1039/c2fo10286b.
Lifestyle intervention is recommended as the primary treatment for mild hypertension and hypercholesterolemia. We studied the effects of a spread containing bioactive milk peptides IPP and VPP, as well as plant sterols, on cardiovascular risk factors in 104 hypertensive, hypercholesterolemic subjects in a randomised, placebo-controlled double-blind intervention. Middle-aged subjects consumed 20 g day⁻¹ of a spread containing 4.2 mg of IPP and VPP as well as 2 g of plant sterols for 10 weeks after a 2 week run-in period. Blood pressure was measured at home 3 times a week. Office blood pressure and 24 h ambulatory blood pressure measurements were performed at the end of the run-in and intervention periods. Blood samples were analysed for serum lipids, plasma glucose and inflammation markers. A significant decrease (-4.1 mmHg vs. -0.5 mmHg, p = 0.007) in systolic blood pressure was seen in the active group, compared to placebo at home measurements. Office blood pressure and 24 h nighttime or daytime ambulatory systolic or diastolic pressure did not differ between the groups. Total (-0.16 vs. 0.25 mmol l⁻¹, p = 0.005) and LDL cholesterol (-0.16 vs. 0.18 mmol l⁻¹, p = 0.006) decreased significantly in the active group compared to the placebo. No significant differences between groups were seen for plasma glucose or inflammation markers. The results thus suggest that milk peptides IPP and VPP and plant sterols, in a low-fat spread matrix, produce a clinically significant reduction in systolic blood pressure as well as serum total and LDL cholesterol without adverse effects. Functional foods that affect 2 major risk factors offer a safe and convenient way to reduce the risk of cardiovascular disease by supporting lifestyle intervention.
生活方式干预被推荐作为轻度高血压和高胆固醇血症的主要治疗方法。我们研究了含有生物活性牛奶肽 IPP 和 VPP 以及植物固醇的涂抹酱对 104 名高血压、高胆固醇血症患者心血管危险因素的影响，这些患者在随机、安慰剂对照、双盲干预中进行了 2 周的导入期后，每天食用 20 克含有 4.2 毫克 IPP 和 VPP 以及 2 克植物固醇的涂抹酱 10 周。在家中每周测量 3 次血压。在导入期和干预期结束时进行办公室血压和 24 小时动态血压测量。分析血液样本中的血清脂质、血浆葡萄糖和炎症标志物。与安慰剂组相比，活性组在家中测量的收缩压显著下降（-4.1mmHg 与-0.5mmHg，p=0.007）。办公室血压和 24 小时夜间或日间动态收缩压或舒张压在两组之间没有差异。总胆固醇（-0.16 与 0.25mmol/L，p=0.005）和 LDL 胆固醇（-0.16 与 0.18mmol/L，p=0.006）在活性组中与安慰剂组相比显著降低。两组之间的血浆葡萄糖或炎症标志物没有显著差异。结果表明，在低脂涂抹酱基质中，牛奶肽 IPP 和 VPP 以及植物固醇可显著降低收缩压以及血清总胆固醇和 LDL 胆固醇，且无不良反应。影响 2 大主要危险因素的功能性食品通过支持生活方式干预，为降低心血管疾病风险提供了一种安全、便捷的方法。
