Department of Pharmacology and Pharmacy, University of Hong Kong, Pokfulam, Hong Kong.
Department of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
Sci Rep. 2017 Jan 24;7:41084. doi: 10.1038/srep41084.
Phytosterols found naturally in plants are known to reduce cholesterol absorption in the gut. The traditional southern Chinese diet typically contains many vegetables and not much meat, and there is high prevalence of lactose intolerance in Chinese; we therefore aimed to test if phytosterols-enriched milk is effective in lowering serum LDL-cholesterol in Chinese. Two hundred and twenty-one participants (41 men and 180 women; age 24-79) without cholesterol-lowering drugs or diabetes mellitus were randomized to daily intake of phytosterols-enriched low-fat milk which contained 1.5 g phytosterols per day (N = 110) or a conventional low-fat milk (N = 111) for three weeks. Fasting bloods were taken before and at the end of the study for the measurement of lipid and glucose profile. Physical examination was also performed. Comparing treatment with control, treatment group had significant decrease in serum LDL-cholesterol level (9.5 ± 2.0%; p < 0.0001). Phytosterols intake also decreased total cholesterol (P < 0.0001) and diastolic blood pressure (P = 0.01). Consumption of a phytosterols-enriched low-fat milk led to a significant fall in LDL-cholesterol, total cholesterol, and diastolic blood pressure in Chinese. This can be recommended as part of a healthy diet for people. (ClinicalTrials.gov identifier: NCT02541201; Date of registration: 26 Aug 2015).
植物固醇天然存在于植物中，已知可减少肠道对胆固醇的吸收。传统的中国南方饮食通常含有大量蔬菜，而肉类较少，而且中国人普遍存在乳糖不耐受；因此，我们旨在测试富含植物固醇的牛奶是否能有效降低中国人的血清 LDL 胆固醇。221 名参与者（41 名男性和 180 名女性；年龄 24-79 岁）没有服用降胆固醇药物或糖尿病，随机分为每天摄入富含植物固醇的低脂牛奶（每天含有 1.5 克植物固醇）（N = 110）或常规低脂牛奶（N = 111），持续 3 周。在研究前后进行禁食采血，以测量血脂和血糖谱。还进行了体格检查。与对照组相比，治疗组血清 LDL 胆固醇水平显著降低（9.5±2.0%；p<0.0001）。植物固醇的摄入还降低了总胆固醇（P<0.0001）和舒张压（P=0.01）。摄入富含植物固醇的低脂牛奶可显著降低中国人的 LDL 胆固醇、总胆固醇和舒张压。这可以作为健康饮食的一部分推荐给人们。（临床试验标识符：NCT02541201；注册日期：2015 年 8 月 26 日）。
