Division of Cardiovascular Surgery, MaRS Centre, Toronto Medical Discovery Tower, University Health Network, ON, Canada.
Can J Physiol Pharmacol. 2012 Mar;90(3):327-35. doi: 10.1139/y2012-007. Epub 2012 Mar 8.
Stem cell research has expanded at an exponential rate, but its therapeutic applications have progressed much more slowly. Currently, the research focuses on understanding embryonic, adult, and inducible pluripotent stem cells. Translation of adult stem cell research has established a definitive benefit that is greater than that of the current standard of care in the field of cardiovascular medicine. The future of stem cell research and therapy will continue to provide novel avenues of diagnostics, therapeutics, and tissue regeneration. Here we discuss a brief history of stem cell research as it transitioned from the 20th to the 21st century. We address lessons learned in the first decade of the new millennium that could help guide others to translate research into therapy across disciplines. Finally, we highlight future goals and challenges that must be overcome and offer some perspective on the bright future of stem cell research and therapy.
干细胞研究呈指数级增长，但治疗应用的进展要慢得多。目前，研究的重点是了解胚胎、成体和诱导多能干细胞。成体干细胞研究的转化已经确立了一个明确的益处，超过了心血管医学领域目前的护理标准。干细胞研究和治疗的未来将继续为诊断、治疗和组织再生提供新的途径。在这里，我们讨论了干细胞研究从 20 世纪到 21 世纪的简要历史。我们探讨了新千年第一个十年中吸取的经验教训，这些经验教训可以帮助指导其他人将研究转化为跨学科的治疗。最后，我们强调了未来必须克服的目标和挑战，并对干细胞研究和治疗的光明未来提供了一些看法。
