钯催化的未保护巯基苯甲酸与苄醇在水中的 S-苄基化反应。
Palladium-catalyzed S-benzylation of unprotected mercaptobenzoic acid with benzyl alcohols in water.
机构信息
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
出版信息
Org Biomol Chem. 2012 Apr 21;10(15):2942-5. doi: 10.1039/c2ob25091h. Epub 2012 Mar 8.
PMID:22402746
Abstract
Palladium-catalyzed S-benzylation of unprotected mercaptobenzoic acids with benzyl alcohols gave only S-benzylated mercaptobenzoic acids in good yields. Water may play an important role for the smooth generation of the (η(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
摘要
钯催化的未保护巯基苯甲酸与苄醇的 S-苄基化反应以良好的收率得到了仅 S-苄基化的巯基苯甲酸。水可能通过激活苄醇的羟基基团来顺利生成（η(3)-苄基)钯物种，从而起到了重要作用。
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