使用Re2O7催化剂，使未受保护的苯胺与苄醇进行化学选择性C-苄基化反应。
Chemoselective C-benzylation of unprotected anilines with benzyl alcohols using Re2O7 catalyst.
作者信息
Nallagonda Rajender, Rehan Mohammad, Ghorai Prasanta
机构信息
Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal , Indore By-pass Road, Bhauri, Bhopal-462066, India.
出版信息
J Org Chem. 2014 Apr 4;79(7):2934-43. doi: 10.1021/jo4028598. Epub 2014 Mar 18.
PMID:24601671
Abstract
An unprecedented dehydrative C-C bond formation between unprotected anilines with benzyl alcohols is disclosed. Re2O7 catalyst (5 mol %) at elevated reaction temperature (80 °C) provided C-benzylanilines with high to excellent yields and with good chemoselectivities (over N-alkylation). A probable mechanism has been proposed based on mechanistic studies.
摘要
本文报道了一种前所未有的、在未保护的苯胺与苄醇之间形成脱水C-C键的反应。在80℃的较高反应温度下，使用5 mol%的Re2O7催化剂，可高产率、高化学选择性（相对于N-烷基化）地得到C-苄基苯胺。基于机理研究提出了一种可能的反应机理。
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