Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA.
Stroke. 2012 Apr;43(4):939-45. doi: 10.1161/STROKEAHA.111.639435. Epub 2012 Mar 8.
Light-to-moderate alcohol consumption has been consistently associated with lower risk of heart disease, but data for stroke are less certain. A lower risk of stroke with light-to-moderate alcohol intake has been suggested, but the dose response among women remains uncertain and the data in this subgroup have been sparse.
A total of 83 578 female participants of the Nurses' Health Study who were free of diagnosed cardiovascular disease and cancer at baseline were followed-up from 1980 to 2006. Data on self-reported alcohol consumption were assessed at baseline and updated approximately every 4 years, whereas stroke and potential confounder data were updated at baseline and biennially. Strokes were classified according to the National Survey of Stroke criteria.
We observed 2171 incident strokes over 1 695 324 person-years. In multivariable adjusted analyses, compared to abstainers, the relative risks of stroke were 0.83 (95% CI, 0.75-0.92) for <5 g/d, 0.79 (95% CI, 0.70-0.90) for 5 to 14.9 g/d, 0.87 (0.72-1.05) for 15 to 29.9 g/d, and 1.06 (95% CI, 0.86-1.30) for 30 to 45 g/d. Results were similar for ischemic and hemorrhagic stroke.
Light-to-moderate alcohol consumption was associated with a lower risk of total stroke. In this population of women with modest alcohol consumption, an elevated risk of total stroke related to alcohol was not observed.
轻至中度饮酒与心脏病风险降低相关，但关于中风的数据则不太确定。有研究提示轻至中度饮酒可降低中风风险，但女性的剂量反应仍不确定，且该亚组的数据较为匮乏。
共有 83578 名无心血管疾病和癌症诊断的护士健康研究女性参与者，于基线时入组，随访至 2006 年。基线时评估了自我报告的饮酒量数据，并大约每 4 年更新一次，而中风和潜在混杂因素数据则在基线和每两年更新一次。中风根据国家卒中调查标准进行分类。
我们观察到 1695324 人年中有 2171 例中风事件。在多变量校正分析中，与不饮酒者相比，饮酒<5g/d、5-14.9g/d、15-29.9g/d 和 30-45g/d 的中风相对风险分别为 0.83（95%CI：0.75-0.92）、0.79（95%CI：0.70-0.90）、0.87（95%CI：0.72-1.05）和 1.06（95%CI：0.86-1.30）。缺血性和出血性中风的结果相似。
轻至中度饮酒与总中风风险降低相关。在这群适度饮酒的女性中，未观察到与饮酒相关的总中风风险升高。
