Pinsky J L, Jette A M, Branch L G, Kannel W B, Feinleib M
Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Am J Public Health. 1990 Nov;80(11):1363-7. doi: 10.2105/ajph.80.11.1363.
The relation between coronary heart disease and disability was examined in 2,576 community-dwelling women and men ages 55-88 years. These Framingham Study participants were originally recruited in 1948-51 for an examination of cardiovascular disease. Twenty-seven years later, remaining members of the cohort were interviewed to ascertain physical abilities, and a score on a disability scale was assigned. Multivariate logistic analyses examined disability in relation to uncomplicated angina pectoris (AP), complicated AP, and coronary heart disease other than AP, controlling for possible confounders. In younger and older women and men, uncomplicated and complicated AP were associated with disability. Coronary heart disease other than AP was associated with disability only in the younger men. Congestive heart failure predicted disability only in the women. These results suggest that onset of AP should be recognized as a critical point in the development of disability and that AP is a better predictor of disability than is myocardial infarction or coronary insufficiency.
在2576名年龄在55至88岁之间的社区居民男女中，研究了冠心病与残疾之间的关系。这些弗明汉研究参与者最初于1948年至1951年被招募来检查心血管疾病。27年后，对该队列的剩余成员进行访谈以确定身体能力，并给出残疾量表评分。多变量逻辑分析研究了残疾与单纯性心绞痛（AP）、复杂性AP以及除AP之外的冠心病之间的关系，并对可能的混杂因素进行了控制。在年轻和老年女性及男性中，单纯性和复杂性AP均与残疾相关。除AP之外的冠心病仅在年轻男性中与残疾相关。充血性心力衰竭仅在女性中预示着残疾。这些结果表明，AP的发作应被视为残疾发展中的一个关键点，并且与心肌梗死或冠状动脉供血不足相比，AP是残疾的更好预测指标。
