Division of General Pediatrics, Children's Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA.
Br J Psychiatry. 2012 Apr;200(4):290-9. doi: 10.1192/bjp.bp.111.101253. Epub 2012 Mar 8.
Associations between specific parent and offspring mental disorders are likely to have been overestimated in studies that have failed to control for parent comorbidity.
To examine the associations of parent with respondent disorders.
Data come from the World Health Organization (WHO) World Mental Health Surveys (n = 51 507). Respondent disorders were assessed with the Composite International Diagnostic Interview and parent disorders with informant-based Family History Research Diagnostic Criteria interviews.
Although virtually all parent disorders examined (major depressive, generalised anxiety, panic, substance and antisocial behaviour disorders and suicidality) were significantly associated with offspring disorders in multivariate analyses, little specificity was found. Comorbid parent disorders had significant sub-additive associations with offspring disorders. Population-attributable risk proportions for parent disorders were 12.4% across all offspring disorders, generally higher in high- and upper-middle- than low-/lower-middle-income countries, and consistently higher for behaviour (11.0-19.9%) than other (7.1-14.0%) disorders.
Parent psychopathology is a robust non-specific predictor associated with a substantial proportion of offspring disorders.
在未能控制父母共病的研究中，特定父母与子女精神障碍之间的关联可能被高估。
研究父母与受访者障碍之间的关联。
数据来自世界卫生组织（WHO）世界心理健康调查（n=51507）。受访者的障碍通过综合国际诊断访谈进行评估，而父母的障碍则通过信息提供者的家族史研究诊断标准访谈进行评估。
尽管在多变量分析中，几乎所有研究的父母障碍（重度抑郁、广泛性焦虑、惊恐、物质和反社会行为障碍以及自杀意念）都与子女障碍显著相关，但发现特异性很小。合并的父母障碍与子女障碍具有显著的次加性关联。所有子女障碍中，父母障碍的人群归因风险比例为 12.4%，在高收入和中高收入国家普遍高于低收入和中低收入国家，而行为障碍（11.0-19.9%）的人群归因风险比例始终高于其他障碍（7.1-14.0%）。
父母的精神病理学是一个强有力的非特异性预测因素，与相当一部分子女障碍有关。
