Comprehensive Epilepsy Program, Department of Neurology, University of Florida Health Sciences Center/Jacksonville, FL 32209, USA.
Epilepsy Behav. 2012 Apr;23(4):437-41. doi: 10.1016/j.yebeh.2012.02.002. Epub 2012 Mar 8.
To determine whether antiepileptic drug (AED) characteristics are associated with medication adherence.
We reviewed pharmacy and clinical records of 108 patients with epilepsy from the indigent care program at Shands-Jacksonville. We calculated the mean medication possession ratio (MMPR) for each AED. Using univariate analysis, we determined whether differences exist in the MMPR of various AEDs. We also determined whether the MMPR differs accordingly to the use of mono- or combination therapy, dosing frequency, release-type, or brand-name formulation. We employed multivariable analysis to determine if these differences persisted in the context of other demographic and clinical variables.
Mean medication possession ratio was higher (better) when using older AEDs, in monotherapy, and with more frequent dosing intervals. These variables remained significant on multivariable analysis.
Our findings contradict some commonly held beliefs on medication adherence and suggest that specific AED characteristics may be superseded by factors such as overall patient satisfaction with the drug regimen.
确定抗癫痫药物（AED）的特征是否与药物依从性相关。
我们回顾了杰克逊维尔 Shands 贫困医疗项目中 108 名癫痫患者的药房和临床记录。我们计算了每种 AED 的平均药物占有比（MMPR）。通过单变量分析，我们确定了各种 AED 的 MMPR 是否存在差异。我们还确定了 MMPR 是否因单药或联合治疗、给药频率、释放类型或品牌配方的使用而有所不同。我们采用多变量分析来确定在其他人口统计学和临床变量的背景下，这些差异是否仍然存在。
使用较老的 AED、单药治疗和更频繁的给药间隔时，平均药物占有比更高（更好）。这些变量在多变量分析中仍然具有显著性。
我们的发现与一些关于药物依从性的普遍观念相矛盾，表明特定的 AED 特征可能被患者对药物治疗方案的总体满意度等因素所取代。
