Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
Trends Endocrinol Metab. 2012 Apr;23(4):169-78. doi: 10.1016/j.tem.2012.02.001. Epub 2012 Mar 10.
Although lipid metabolism and host defense are widely considered to be very divergent disciplines, compelling evidence suggests that host cell handling of self- and microbe-derived (e.g. lipopolysaccharide, LPS) lipids may have common evolutionary roots, and that they indeed may be inseparable processes. The innate immune response and the homeostatic network controlling cellular sterol levels are now known to regulate each other reciprocally, with important implications for several common diseases, including atherosclerosis. In the present review we discuss recent discoveries that provide new insight into the bidirectional crosstalk between reverse cholesterol transport and innate immunity, and highlight the broader implications of these findings for the development of therapeutics.
尽管脂质代谢和宿主防御被广泛认为是非常不同的学科，但有确凿的证据表明，宿主细胞处理自身和微生物来源的（例如脂多糖，LPS）脂质可能具有共同的进化根源，实际上它们可能是不可分割的过程。先天免疫反应和控制细胞固醇水平的动态平衡网络现在被认为是相互调节的，这对几种常见疾病（包括动脉粥样硬化）有重要影响。在本综述中，我们讨论了最近的发现，这些发现为胆固醇逆向转运和先天免疫之间的双向相互作用提供了新的见解，并强调了这些发现对治疗药物开发的更广泛意义。
