Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.
Toxicon. 2012 Sep 15;60(4):449-54. doi: 10.1016/j.toxicon.2012.02.006. Epub 2012 Mar 3.
Tracing the evolutionary history of proteins can reveal insights into gene alterations responsible for changes in structure and function. Here, the origin of snake venom metalloproteinases was rigorously reassessed using phylogenetics and the reconstruction of ancestral sequences. Basal SVMPs are most closely related to ADAM 7, 28 and decysin-1 proteins. Reconstructing the evolutionary history of these proteins and their hypothetical ancestors reveals progressive alterations in the amino acid composition and structural characteristics of ADAMs/SVMPs through evolutionary time.
追踪蛋白质的进化历史可以揭示导致结构和功能变化的基因改变的见解。在这里，使用系统发育学和祖先序列重建来严格重新评估蛇毒金属蛋白酶的起源。基底 SVMP 与 ADAM 7、28 和 decysin-1 蛋白最密切相关。重建这些蛋白质及其假设祖先的进化历史表明，ADAM/SVMP 的氨基酸组成和结构特征随着进化时间的推移而逐渐改变。
